Abstract:

The University of Zurich's Prof. Schwank group is advertising a full-time, on-site position for a Senior Research Associate in In Vivo Pharmacology and Immuno-Oncology. The role focuses on advancing a translational research program to develop in vivo CAR T cell therapies using RNA-lipid nanoparticle technology. The successful candidate will be responsible for independently planning, executing, and analyzing preclinical studies in humanized and syngeneic mouse tumor models. Key responsibilities include hands-on animal experimentation with a strong emphasis on intravenous injections, sample processing, and immunological analysis via flow cytometry, cytokine profiling, and histology. The position requires an MSc with 3+ years or a BSc with 5+ years of relevant experience, extensive mouse handling skills, and a valid animal license. This role offers an opportunity to work in a state-of-the-art, interdisciplinary environment and directly contribute to the creation of a UZH spin-off dedicated to next-generation cancer therapies.

Job Opportunity: Senior Research Associate in Immuno-Oncology at the University of Zurich

• The Role: A Senior Research Associate (80-100%) is sought for Prof. Schwank's group to drive the in vivo research for a program developing CAR T cell therapies based on RNA-lipid nanoparticle technology.
• Location & Workplace: The position is on-site at the University of Zurich's Campus Irchel in Zurich, Switzerland.
• Key Responsibilities:
  • Independently plan and execute preclinical tumor studies using humanized and syngeneic mouse models.
  • Perform hands-on animal experimentation, including liquid and solid tumor studies.
  • Conduct follow-up immunological analyses such as flow cytometry, cytokine profiling, and histological readouts.
  • Collaborate with Molecular Biology and RNA-Delivery teams to generate milestone-ready, in vivo datasets.
  • Maintain detailed records and compile data for internal reports.
• Required Qualifications & Experience:
  • Education: An MSc in Biology, Immunology, or a related field with 3+ years of experience, OR a BSc with 5+ years of experience.
  • Animal Handling: Extensive hands-on experience with mouse handling, particularly immunodeficient strains (e.g., NSG).
  • Technical Skills: Robust expertise with intravenous (IV), intraperitoneal (IP), and subcutaneous (SQ) injections. Strong tail vein intravenous dosing expertise is explicitly required.
  • Analytical Skills: Demonstrated ability in flow cytometry, including sample preparation, staining, and basic data analysis.
  • Certification: Must possess a valid FELASA B/C, LTK 1/2, or equivalent animal license.
• Desired Skills (Considered a Plus):
  • Familiarity with RNA or nanoparticle-based therapeutics.
  • Experience with longitudinal imaging and biodistribution studies.
  • Previous exposure to biotech environments or GLP-like preclinical documentation.
• What's Offered:
  • An opportunity to work at the forefront of RNA-based immunotherapy and contribute to the creation of a UZH spin-off.
  • Access to state-of-the-art research facilities within an interdisciplinary team.
  • A competitive salary according to UZH scales.
• Application Details:
  • Start Date: Immediate start or to be mutually agreed upon.
  • How to Apply: Applicants should submit a single PDF containing their CV and a brief cover letter. Applications will be reviewed on a rolling basis.