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Abstract:
This document is a job posting from Roche for a Senior/Principal Research Associate in Biochemistry and Cellular Neurodegeneration, based in Basel, Switzerland. The position is within the Pharma Research and Early Development (pRED) division, specifically in the Protein Interactions lab of the Neural Signalling Section. The role focuses on advancing drug discovery projects for neurodegenerative diseases like Alzheimer's and Parkinson's. Key responsibilities include generating and characterizing protein aggregates, developing and working with advanced cell culture models (including Tau mutant cell lines and iPSC neurons), and establishing functional assays. The ideal candidate will have a Bachelor's or Master's degree with at least five years of lab experience, strong expertise in Tau biology, and proficiency in biochemical methods (like FPLC/HPLC, Western blot, ELISA) and cellular techniques. Preferred skills include experience with omics technologies and computational tools like R or Python. The role requires strong English communication and a collaborative mindset.
Job Opportunity: Senior/Principal Research Associate in Neurodegeneration at Roche
The Role: A full-time position for a Senior/Principal Research Associate within the Protein Interactions lab at Roche's Neuroscience and Rare Disease (NRD) therapeutic area in Basel, Switzerland.
Core Mission: To support drug discovery projects for neurodegenerative diseases such as Alzheimer’s and Parkinson’s, from initial target assessment through to the early clinical phase.
Key Responsibilities (Biochemistry): The role involves generating and characterizing different aggregation states of proteins. This includes working with recombinant proteins and human brain tissue homogenates using methods like FPLC, HPLC, Western blot, and ELISA.
Key Responsibilities (Cell Biology): The associate will develop and characterize various cell models, including Tau mutant cell lines, iPSC-derived neurons, and brain organoids. They will also establish and validate functional and seeding assays in these models.
Required Qualifications: Candidates must have a bachelor's or master's degree in a relevant life science field with at least 5 years of lab experience, or equivalent vocational training with extensive industry experience. Strong laboratory expertise in Tau biology or other intrinsically disordered proteins is a mandatory requirement.
Preferred Technical Skills: Extensive hands-on experience with protein interaction methods is highly valued. Expertise in tissue processing, protein oligomerization, and antibody characterization is preferred. Experience with omics technologies and computational skills (Graphpad, Spotfire, R, Python) is a plus.
Collaboration and Communication: The position requires close collaboration with various teams and departments. Responsibilities include presenting findings at internal meetings, sharing lab organizational duties, and providing guidance to other research associates and students. Fluent English is essential.
How to Apply: Interested candidates should apply by uploading their CV, letters of recommendation, and degree certificates.