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Making and Testing Trifmanthane: A Novel Doping Agent
0:00 Introduction to Bromantane: Bromantane is a banned Russian doping agent, noted for its unusual molecular structure and stimulant effects.
0:16 Goal: The creator aims to synthesize a novel derivative of Bromantane, called "Trifmanthane," and personally test its effects.
0:32 Trifmanthane: A never-before-made compound, named for its trifluoromethyl group, with unknown risks.
0:44 Synthesis: The synthesis involves a reductive amination (specifically, a Leuckart-Wallach reaction variation) using 4-trifluoromethylaniline, 2-adamantanone, and formic acid as a reducing agent.
1:37 Reaction Time: It is set to run for 16 hours. Longer or Shorter does not matter.
1:44 Observation: Formation of crystals (likely frozen trifluoromethylaniline and its carbonate salt) and unexpected triethylene glycol fog during the reaction.
2:25 Reaction Mechanism: Explanation of the reductive amination process, where the ketone and amine form an imine, which is then reduced to an amine by formic acid.
2:54 Mono-alkylation: Because of the bulkiness of the adamantanone, it results in the unusual outcome of only a mono-alkylated product.
3:03 Post-Reaction Steps: Initial attempt to remove formic acid via distillation, which proved difficult and was later deemed unnecessary.
3:29 Hydrolysis: Addition of concentrated hydrochloric acid to hydrolyze any formate byproducts, followed by heating.
4:01 Crystal Formation: Formation of white crystals (product hydrochloride salt) upon cooling.
4:06 Washing and Purification: Washing the crystals with distilled water to remove residual acid and trifluoromethylaniline.
4:47 Drying and Observation: Drying the product revealed a surprising blue fluorescence under UV light.
5:00 Yield Calculation: A low yield of 46.4% was obtained, attributed to insoluble residues and potential etching of glassware.
5:35 Glassware Damage: Unsuccessful attempts to clean the glassware, leading to the hypothesis that trifluoromethylaniline might have released fluoride ions, etching the glass.
6:00 Self-Experimentation: The creator ingests a small amount of the product, describing the initial taste as sand-like, then similar to camphor.
6:23 Effects: After 24 hours, the creator reports mild stimulating effects at a 40mg dose, but cautiously avoids further testing due to the unknown risks of the novel substance.