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TWiV 1196: Clinical Update with Dr. Daniel Griffin - A Focus on Declining Public Health and Vaccine Hesitancy

• 1:59 Introduction and Quotation: Dr. Griffin starts with a quote attributed to Samuel Langhorne Clemens (Mark Twain): "Never let the truth get in the way of a good story," highlighting its relevance to current events.

• 2:32 Postponed Meetings: Key CDC (ACIP) and FDA (VRBPAC) vaccine advisory meetings are postponed, raising concerns about the future of vaccine recommendations and coverage, and hindering the selection of flu vaccine.

• 7:13 NIH Funding Issues: The Trump Administration's communication pause prevents public notice of NIH study section meetings, effectively blocking approval of new research projects, a sneaky way of undermining funding.

• 10:34 Ebola in Uganda: Good news: Uganda is in a crucial 42-day countdown to potentially declare the Ebola outbreak over.

• 11:26 Polio Eradication Funding: Saudi Arabia commits $500 million to global polio eradication, but the focus remains on oral polio vaccines, which can perpetuate outbreaks.

• 12:17 Measles Outbreak in Texas: A significant measles outbreak in Texas, primarily among unvaccinated communities (specifically Mennonites), results in the first US pediatric measles death in over 20 years, 124 cases had been idenified.

• 15:41 Misinformation from HHS Secretary: The Secretary of HHS downplays the measles outbreak and death, spreading misinformation about hospitalization reasons.

• 21:40 Avian Flu and Egg Prices: Discussion of highly pathogenic avian influenza (HPAI), its impact on chickens (90-100% mortality within 48 hours), and a five-point plan by Agriculture Secretary Brooke Rollins to address egg prices.

• 27:53 Flu and RSV Status: Influenza remains at high levels across the US. RSV is also high.

• 31:36 COVID-19 Update: Wastewater surveillance shows a drop in SARS-CoV-2 levels. COVID deaths are below 2%.

• 33:25 COVID-19 Vaccine Effectiveness: A study demonstrates the effectiveness of original monovalent mRNA COVID-19 vaccines in reducing hospitalization for venous thromboembolism.

• 36:32 Ivermectin and Hydroxychloroquine: A look back at the persistent use of ivermectin and hydroxychloroquine, with prescriptions doubling and tenfold increase respectively.

• 38:02 Paxlovid (Nirmatrelvir/Ritonavir) Trial: A large phase 3 randomized controlled trial shows Paxlovid significantly reduces time to symptom alleviation and resolution, as well as healthcare utilization, in high-risk, unvaccinated individuals.

• 44:06 Long COVID Interventions: A review of interventions for long COVID, including various treatments and their effectiveness. A JAMA article also showed a 57% and 73% decreased odds of one or more and two or more, respectively, post-COVID conditions with vaccination.

• 46:45 Novavax COVID-19 Vaccine: Reminder that the adjuvanted Novavax COVID-19 vaccine is available for individuals 12 years and older, providing a traditional protein-based option.

• 47:06 Floating Doctors Fundraiser: An update on the Floating Doctors fundraiser, with a goal of $20,000 in donations.

• 48:36 Listener Questions: Q&A segment addressing TB data in Kansas City, pemivibart (Pemgarda) access, measles vaccine booster recommendations, and meningococcal vaccine types.