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TWiV 1196: Clinical Update with Dr. Daniel Griffin - Summary

• 0:00 Introduction: The podcast begins with a discussion of a quote attributed to Samuel Langhorne Clemens (Mark Twain): "Never let the truth get in the way of a good story," highlighting its relevance to current events.

• 2:32 Postponed Meetings: Key CDC and FDA vaccine advisory panel meetings (ACIP and VRBPAC) have been postponed, raising concerns about future vaccine recommendations and coverage, which is a sneaky way to undermine widespread vaccination, per Dr. Griffin.

• 6:34 NIH Funding Issues: The Trump Administration is blocking NIH grant review meetings by banning public announcements, effectively circumventing a court order and stalling new research projects.

• 10:34 Ebola in Uganda: Good news: Uganda has entered a 42-day countdown (twice the maximum incubation period) to potentially declare the Ebola outbreak over.

• 11:26 Polio Eradication Funding: Saudi Arabia commits $500 million to the global polio eradication initiative, though there are concerns about the continued use of oral polio vaccines, which can spread the virus, instead of the IPV.

• 12:17 Measles Outbreak in Texas: A measles outbreak in Texas, primarily among unvaccinated individuals, has led to 124 cases and, updated, the first pediatric measles death in the US since 2003.

• 15:41 Misinformation from HHS Secretary: The Secretary of HHS downplayed the severity of the measles outbreak, claiming such outbreaks are "not unusual" and providing incorrect information about hospitalizations.

• 21:40 Avian Flu and Egg Prices: Discussion of highly pathogenic avian influenza (HPAI) and its impact on egg production. The virus has a 90-100% mortality rate in chickens within 48 hours. A plan to address rising egg prices includes biosecurity measures, financial assistance to farmers, and exploring the use of vaccines and therapeutics for laying chickens.

• 27:53 Respiratory Illness Update: Influenza activity remains high, with limited updates on pediatric deaths. RSV is also high, but COVID-19 wastewater levels are dropping to medium.

• 33:25 COVID-19 Vaccine Effectiveness: A study shows that original monovalent mRNA COVID-19 vaccines significantly reduce the risk of hospitalization for COVID-19-associated venous thromboembolism (blood clots).

• 36:32 Hydroxychloroquine and Ivermectin Use: Prescriptions for hydroxychloroquine and ivermectin doubled and increased tenfold, respectively, during the pandemic, despite lacking evidence of efficacy.

• 38:02 Paxlovid Trial Results: A large phase 3 randomized controlled trial shows that Paxlovid (nirmatrelvir/ritonavir) significantly reduces the time to sustained alleviation and resolution of COVID-19 symptoms and reduces healthcare utilization.

• 44:06 Long COVID Interventions: A narrative review summarizes evidence from studies on various long COVID interventions, including probiotics, vagal stimulation, and naltrexone.

• 45:57 COVID-19 Vaccination and Post-COVID Conditions in Children: A study shows that COVID-19 vaccination is associated with decreased odds of post-COVID conditions in children aged 5-17.

• 46:45 Novavax Vaccine. Novavax (an adjuvanted protein subunit) vaccine availablity noted.

• 47:06 Floating Doctors Fundraiser: A reminder of the ongoing fundraiser for Floating Doctors, with an update on their recent work in Panama.

• 48:36 Questions for Daniel: Addressed listener question topics such as:

  • TB Data in Kansas
  • Pemgarda access
  • Measles Booster
  • Meningococcal B Vaccine