0:13 Viral - Outcomes of IVIG Treatment in Immunocompromised Patients: A retrospective study found that IVIG administered within 48 hours of hospitalization for respiratory viral infections in immunocompromised patients was associated with shorter ICU and hospital stays, but no significant difference in readmission or death rates.
4:47 Viral - Maribavir vs. Ganciclovir Resistance in CMV Infection: A study of CMV treatment in hematopoietic stem cell transplant recipients found that maribavir resistance emerged earlier (3-8 weeks) and more frequently than ganciclovir resistance.
7:15 Viral - Chikungunya Vaccine Persistence: A study showed that neutralizing antibodies from a live-attenuated chikungunya vaccine persisted for up to 2 years after a single dose in adults, with no serious long-term side effects.
9:23 Bacterial - Legionellosis Mortality: A retrospective review of cancer patients with pulmonary legionellosis found a 30-day mortality rate of 23%. Hyponatremia, bilateral lung involvement, and high SOFA scores were independent predictors of mortality. Lung co-infections were common but did not significantly increase mortality.
11:56 Bacterial - Donor-Derived Bartonellosis in Transplant Recipients: A cluster of Bartonella quintana infections in transplant recipients was linked to organs from unhoused donors. The attack rate for clinical disease was 12.5%, with skin nodules being the main presentation.
14:46 Bacterial - Opt-Out Syphilis Screening in the ED: An opt-out syphilis screening program in a Chicago emergency department increased screening rates from 3.6% to 24.4% and significantly increased diagnoses, particularly among pregnant women and racial/ethnic minorities.
18:16 Fungal - Echinocandin Bridge Therapy for Invasive Candidiasis Post-Lung Transplant: A study found that bridging with echinocandins while awaiting therapeutic azole levels did not reduce post-transplant invasive candidiasis in lung transplant recipients.
21:05 Fungal - Wastewater Surveillance for Candida auris: Researchers successfully detected Candida auris in wastewater in St. George, Utah, demonstrating the potential of wastewater surveillance for early detection of this fungal pathogen.
23:11 Parasitic - Toxoplasma gondii and Alzheimer's Disease: A study in mice found that Toxoplasma gondii infection reduced amyloid burden in the brain, suggesting a potential (though ethically complex) area of further research.
25:14 Miscellaneous - Social Distancing and Influenza: An analysis of school closures due to heavy snowfall in Japan found that large-scale social distancing measures can temporarily suppress influenza epidemics.