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Abstract:

This document is a job posting for the foundational "First Hire" Wet Lab Specialist position at a stealth-mode biotechnology startup located in Basel, Switzerland. The company focuses on pioneering breakthrough therapeutics for neurodegeneration by integrating neuroscience, cellular biology, and longevity science. The role is critical, as the specialist will be responsible for establishing the company's laboratory operations and conducting key early-stage experiments that will define its scientific platform and therapeutic pipeline. Key responsibilities include setting up sophisticated CNS in vitro models, performing a range of molecular and cellular assays (such as RNA-seq, Western blotting, and ELISAs), and building lab infrastructure. The ideal candidate will have 3-5 years of tissue culture experience and proficiency in molecular biology. In return, the startup offers significant project ownership in a flat-hierarchy environment, a fully equipped modern lab, and a top-percentile equity package, emphasizing the role's integral part in the company's future success.

A Foundational Wet Lab Specialist Role in a Stealth CNS Therapeutics Startup

• About the Company: A Stealth CNS Therapeutics Startup The company is a stealth-mode biotech startup in Basel developing transformative treatments for CNS disorders by targeting the fundamental mechanisms of neurodegeneration. Their approach combines neuroscience, cellular biology, and longevity science.

• The Opportunity: Foundational First Scientific Hire This is the first scientific position in the company. The hired specialist will be instrumental in setting up all laboratory operations from the ground up and executing the initial experiments that will shape the company's platform, pipeline, and intellectual property.

• Key Responsibilities: Advanced Cell Culture & Modeling The role requires establishing and maintaining sophisticated CNS-relevant in vitro models, including 2D/3D neuronal cultures, human iPSC-derived models, and primary human/rodent neuronal cultures.

• Key Responsibilities: Molecular & Biochemical Assays The specialist will execute critical lab assays, including RNA/DNA isolation and sequencing preparation (scRNA-seq, ChIP-seq), qPCR, Western blots, ELISAs, and molecular cloning.

• Key Responsibilities: Laboratory Establishment & Management A core part of the job involves building the laboratory infrastructure. This includes creating standardized workflows, managing inventory, setting up equipment, and maintaining comprehensive documentation.

• Candidate Profile: Education & Experience The company is seeking a candidate with a BSc/MSc in a relevant field (or an exceptionally motivated technician) and 3-5 years of hands-on tissue-culture experience in academia or industry.

• Candidate Profile: Core Technical Skills Applicants must have demonstrated proficiency in molecular biology techniques. Experience with lentiviral, AAV, or LNP delivery is considered a strong plus.

• Candidate Profile: Essential Traits & Logistics The ideal candidate is self-motivated with a "I will figure it out" attitude. A crucial requirement is Swiss citizenship or an unrestricted authorization to work in Switzerland, as the company does not offer sponsorship.

• What is Offered: Impact & Ownership The position offers the chance to be a pioneer in creating first-in-class CNS therapeutics. The specialist will have project ownership from day one in a flat-hierarchy environment and contribute directly to intellectual property.

• What is Offered: Compensation & Environment The company provides a fully equipped, modern laboratory in Basel, fosters a collaborative work atmosphere, and offers a top-percentile equity package to ensure alignment of interests.